Dicer and Drosha predict outcomes in ovarian cancer

Running head: Expressions of microRNAs, Dicer and Drosha in neuroblastoma

Affiliation: Graduate Institute of Life Science, National Defense Medical Center, Taipei 115, Taiwan Genomics Research Center, Academia Sinica, Taipei 115, Taiwan 3 PNN technologies Inc, Woodbridge, VA 22195, USA Department of Pediatrics/Hematology-Oncology, University of California San Diego Medical Center, CA 92103-8447, USA Children's Oncology Group Statistics and Data Center, University of ...

Does the Ovarian Stimulation Phase Length Predict In vitro Fertilization Outcomes

Down-regulation of dicer expression in ovarian cancer tissues.

OBJECTIVES Although numerous recent studies have focused on analyses of microRNA expression profiles in cancer cells, the expression patterns of the enzymes responsible for the generation of miRNAs remains largely unexplored. The purpose of this study was to investigate whether Dicer mRNA expression is altered during progression of ovarian cancer. DESIGN AND METHODS Total RNA was extracted fr...

Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival

BACKGROUND Dicer and Drosha are important enzymes for processing microRNAs. Recent studies have exhibited possible links between expression of different miRNAs, levels of miRNA processing enzymes, and cancer prognosis. We have investigated the prognostic impact of Dicer and Drosha and their correlation with miR-126 expression in a large cohort of non-small cell lung cancer (NSCLC) patients. We ...

Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.

Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) by Export in 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a deeper understanding of the contribution of each of these maturation steps, we deleted DROSHA, XPO5, and DICER in the same human cell line, a...